Journal: Acta Obstetricia et Gynecologica Scandinavica

Article Title: Clinical value of early viscoelastometric point‐of‐care testing during postpartum hemorrhage for the prediction of severity of bleeding: A multicenter prospective cohort study in the Netherlands

doi: 10.1111/aogs.14172

Figure Lengend Snippet: Baseline characteristics for women with postpartum hemorrhage and a valid corresponding fibrin‐based thromboelastometry amplitude of clot firmness at 5 min (FIBTEM A5) and fibrinogen measurement between 800 and 1500 ml of blood loss following birth

Article Snippet: These samples were taken for full blood count, fibrinogen measurement (according to the Clauss method) and FIBTEM A5 measurement performed on a ROTEM ® Delta device (Tem International GmbH).

Techniques: FIBTEM Assay

Journal: Acta Obstetricia et Gynecologica Scandinavica

Article Title: Clinical value of early viscoelastometric point‐of‐care testing during postpartum hemorrhage for the prediction of severity of bleeding: A multicenter prospective cohort study in the Netherlands

doi: 10.1111/aogs.14172

Figure Lengend Snippet: Distribution of outcomes categorized to fibrinogen concentrations and fibrin‐based thromboelastometry amplitude of clot firmness at 5 min (FIBTEM A5) values measured between 800 and 1500 ml of blood loss following birth

Article Snippet: These samples were taken for full blood count, fibrinogen measurement (according to the Clauss method) and FIBTEM A5 measurement performed on a ROTEM ® Delta device (Tem International GmbH).

Techniques: FIBTEM Assay

Journal: Acta Obstetricia et Gynecologica Scandinavica

Article Title: Clinical value of early viscoelastometric point‐of‐care testing during postpartum hemorrhage for the prediction of severity of bleeding: A multicenter prospective cohort study in the Netherlands

doi: 10.1111/aogs.14172

Figure Lengend Snippet: ROC curves for fibrinogen (black) and fibrin‐based thromboelastometry amplitude of clot firmness at 5 min (FIBTEM A5) (gray) for progression to severe postpartum hemorrhage when measured between 800 and 1500 ml of blood loss following birth

Article Snippet: These samples were taken for full blood count, fibrinogen measurement (according to the Clauss method) and FIBTEM A5 measurement performed on a ROTEM ® Delta device (Tem International GmbH).

Techniques: FIBTEM Assay

Journal: eClinicalMedicine

Article Title: Efficacy and safety of human fibrinogen concentrate (BT524) in patients with major haemorrhage undergoing major orthopaedic or abdominal surgery (AdFIrst): a randomised, active-controlled, multicentre, partially blinded, phase 3 non-inferiority trial

doi: 10.1016/j.eclinm.2025.103264

Figure Lengend Snippet: Comparison of fibrinogen correction following administration of FC or FFP/Cryo . (A) Percentage of patients with successful correction of functional fibrinogen level after the intraoperative administration of FC or FFP/Cryo. For patients with successful correction, the percentage with correction within the stated time period relative to the start of drug administration is also shown. The p value describes the difference between FC and FFP/Cryo over all defined time categories (B) Box-and-whisker plot depicting FIBTEM A10 as a measure of the functional fibrinogen level in patients as determined by ROTEM across different time points. Boxes represent the median, lower and upper quartiles (25th and 75th percentile, respectively), with whiskers indicating the minimum and maximum values. The whisker length is restricted to 1·5 times the IQR from the median; data points beyond this range are represented as individual dots. The mean value is indicated by a cross. End of surgery may have been before the 90-min time point. Cryo, cryoprecipitate; FC, human fibrinogen concentrate; FFP, fresh frozen precipitate; FIBTEM A10, functional fibrinogen level from clot amplitude after 10 minutes; ROTEM, rotational thromboelastometry.

Article Snippet: Spinal surgery: FC dose was calculated based on body weight (BW) and functional fibrinogen level from clot amplitude after 10 min (FIBTEM A10; measured intraoperatively by rotational thromboelastometry [ROTEM] using ROTEM delta and ROTEM sigma devices [Werfen GmbH, Munich, Germany]), with the aim to restore patient's individual baseline fibrinogen level.

Techniques: Comparison, Functional Assay, Whisker Assay, FIBTEM Assay

Journal: BioMed Research International

Article Title: Thromboelastography and Thromboelastometry in Assessment of Fibrinogen Deficiency and Prediction for Transfusion Requirement: A Descriptive Review

doi: 10.1155/2018/7020539

Figure Lengend Snippet: Summary of correlations between functional fibrinogen (FF) TEG/ROTEM FIBTEM and fibrinogen levels.

Article Snippet: , A prospective study of 517 adult trauma patients with a systolic blood pressure (SBP) of < 90 mmHg and a median ISS of 14 (8–27). Citrated blood was collected within 20 min of arrival in the emergency department (ED). , Blood samples were analyzed within 2 h of blood draw, with a ROTEM delta instrument, at 37°C. Two separate ROTEM assays were performed for each patient, the EXTEM, measuring tissue factor-initiated clotting, and the FIBTEM, with the addition of cytochalasin D, a platelet inhibitor as per manufacturer's protocols. Fibrinogen levels were determined with the Clauss method using STA Fibrinogen (Stago, Asnières sur Seine, France) and Siemens Thrombin (Sysmex UK, Milton Keynes, UK) reagents. , EXTEM and FIBTEM measures of A5 and maximal clot formation (MCF) were significantly correlated with Clauss fibrinogen levels, and the correlations between FIBTEM A5 and MCF were slightly stronger than EXTEM (r 2 = 0.44 vs. 0.35 and 0.27 vs. 0.26). EXTEM and FIBTEM A5 gave a receiver operating characteristic curve area of 0.8 (95% confidence interval 0.7–0.9, p<0.001) for discriminating patients with admission fibrinogen levels below 1.5 g/L. , [ ] .

Techniques: Functional Assay, FIBTEM Assay, Saline, Clinical Proteomics, Concentration Assay, Software, Transformation Assay, Modification, Inhibition, Coagulation, Transplantation Assay, Derivative Assay, Diagnostic Assay, Sampling, Neutralization, Control, Dissection

Journal: BioMed Research International

Article Title: Thromboelastography and Thromboelastometry in Assessment of Fibrinogen Deficiency and Prediction for Transfusion Requirement: A Descriptive Review

doi: 10.1155/2018/7020539

Figure Lengend Snippet: Clinical evaluation of TEG and ROTEM functional fibrinogen tests for diagnosis of coagulopathy (hypofibrinogenemia), prediction of transfusion requirements and mortality.

Article Snippet: , A prospective study of 517 adult trauma patients with a systolic blood pressure (SBP) of < 90 mmHg and a median ISS of 14 (8–27). Citrated blood was collected within 20 min of arrival in the emergency department (ED). , Blood samples were analyzed within 2 h of blood draw, with a ROTEM delta instrument, at 37°C. Two separate ROTEM assays were performed for each patient, the EXTEM, measuring tissue factor-initiated clotting, and the FIBTEM, with the addition of cytochalasin D, a platelet inhibitor as per manufacturer's protocols. Fibrinogen levels were determined with the Clauss method using STA Fibrinogen (Stago, Asnières sur Seine, France) and Siemens Thrombin (Sysmex UK, Milton Keynes, UK) reagents. , EXTEM and FIBTEM measures of A5 and maximal clot formation (MCF) were significantly correlated with Clauss fibrinogen levels, and the correlations between FIBTEM A5 and MCF were slightly stronger than EXTEM (r 2 = 0.44 vs. 0.35 and 0.27 vs. 0.26). EXTEM and FIBTEM A5 gave a receiver operating characteristic curve area of 0.8 (95% confidence interval 0.7–0.9, p<0.001) for discriminating patients with admission fibrinogen levels below 1.5 g/L. , [ ] .

Techniques: Functional Assay, Biomarker Discovery, Saline, Concentration Assay, Clinical Proteomics, Sampling, FIBTEM Assay, Coagulation, Lysis, Transplantation Assay